By Kolio D. Troev
Phosphonic acid esters are intermediates within the synthesis of significant periods of compounds akin to alpha-aminophosphonic acids, bisphosphonates, epoxyalkylphosphonates, alpha-hydroxyalkylphosphonates, phosphoramides, poly(alkylene H-phosphonate)s, poly(alkylene phosphate)s, nucleoside H-phosphonates. The synthesis of every of those compound sessions is reviewed in detail.
Alpha-Aminophosphonic acids are a big category of biologically lively compounds, that have bought an expanding quantity of cognizance simply because they're thought of to be structural analogues of the corresponding Alpha-amino acids. The utilities of alpha-aminophosphonates as peptide mimics, haptens of catalytic antibodies, enzyme inhibitors, inhibitors of cancers, tumours, viruses, antibiotics and pharmacologic brokers are good documented. Alpha-Hydroxyalkanephosphonates are compounds of vital organic and medicinal purposes. Dialkyl epoxyalkylphosphonates are of curiosity as a result of their use as intermediates within the synthesis of bioactive components, and as modifiers of normal and artificial polymers. Bisphosphonates are medications which have been commonplace in several bone ailments, and feature lately been used effectively opposed to many parasites. Poly(alkylene H-phosphonate)s and poly(alkylene phosphate)s are promising, biodegradable, water soluble, new polymer-carriers of gear. Nucleoside H-phosphonates appear to be the main appealing applicants as beginning fabrics within the chemical synthesis of DNA and RNA fragments. The 5’-hydrogen phosphonate-3’-azido-2’,3’-dideoxythimidine is among the most important anti-HIV prodrug, that is at the moment in scientific trials.
Chapters evaluation the synthesis; actual and spectral homes (1H, 13C, 31P and 17O NMR data); attribute reactions; very important periods of compounds in line with those esters of H-phosphonic acid; their program as physiologically energetic components, flame retardants, catalysts, warmth and light stabilizers, lubricants, scale inhibitors, polymer-carriers of medicines; training of H-phosphonate diesters and normal approaches for carrying out crucial reactions.
* offers rules for the synthesis of phosphonates, phosphoramides and diesters of phosphonic acid (new phosphorus-containing compounds)
* studies constitution, spectra and organic job of H-phosphonates and their derivatives
* examines new parts of program of phosphorus-containing compounds
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Additional info for Chemistry and Application of H-Phosphonates
Chemistry and Application of H-Phosphonates by Kolio D. Troev